%0 Journal Article
	%A Mohamed K. Metwally and  Sherif H. El-Gohary and  Kyung Min Byun and  Seung Moo Han and  Soo Yeol Lee and  Min Hyoung Cho and  Gon Khang and  Jinsung Cho and  Tae-Seong Kim
	%D 2014
	%J International Journal of Biomedical and Biological Engineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 92, 2014
	%T Influence of Optical Fluence Distribution on Photoacoustic Imaging
	%U https://publications.waset.org/pdf/9999048
	%V 92
	%X Photoacoustic imaging (PAI) is a non-invasive and
non-ionizing imaging modality that combines the absorption contrast
of light with ultrasound resolution. Laser is used to deposit optical
energy into a target (i.e., optical fluence). Consequently, the target
temperature rises, and then thermal expansion occurs that leads to
generating a PA signal. In general, most image reconstruction
algorithms for PAI assume uniform fluence within an imaging object.
However, it is known that optical fluence distribution within the
object is non-uniform. This could affect the reconstruction of PA
images. In this study, we have investigated the influence of optical
fluence distribution on PA back-propagation imaging using finite
element method. The uniform fluence was simulated as a triangular
waveform within the object of interest. The non-uniform fluence
distribution was estimated by solving light propagation within a
tissue model via Monte Carlo method. The results show that the PA
signal in the case of non-uniform fluence is wider than the uniform
case by 23%. The frequency spectrum of the PA signal due to the
non-uniform fluence has missed some high frequency components in
comparison to the uniform case. Consequently, the reconstructed
image with the non-uniform fluence exhibits a strong smoothing
effect.

	%P 1108 - 1112