{"title":"Highly-Efficient Photoreaction Using Microfluidic Device","authors":"Shigenori Togashi, Yukako Asano","volume":92,"journal":"International Journal of Chemical and Molecular Engineering","pagesStart":755,"pagesEnd":759,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/9998903","abstract":"
We developed an effective microfluidic device for photoreactions with low reflectance and good heat conductance. The performance of this microfluidic device was tested by carrying out a photoreactive synthesis of benzopinacol and acetone from benzophenone and 2-propanol. The yield reached 36% with an irradiation time of 469.2 s and was improved by more than 30% when compared to the values obtained by the batch method. Therefore, the microfluidic device was found to be effective for improving the yields of photoreactions.<\/p>\r\n","references":"[1]\tRoberts, J. D. and M. C. Caserio; Basic Principles of Organic Chemistry, 2nd ed., W. A. Benjamin, Inc., Menlo Park, CA, USA, 1977.\r\n[2]\tHessel, V., S. Hardt and H. L\u00f6we eds.; Chemical Micro Process Engineering: Fundamentals, Modeling and Reactions, Wiley-VCH, Weinheim, Germany, 2004.\r\n[3]\tHessel, V., H. L\u00f6we, A. M\u00fcller and G. Kolb eds.; Chemical Micro Process Engineering: Processing and Plants, Wiley-VCH, Weinheim, Germany, 2005.\r\n[4]\tBenson, R. S. and J. W. Ponton; \"Process Miniaturisation\uf0beA Route to Total Environmental Acceptability?,\u201d Chem.Eng.Res.Des., A71, 1993, pp.160-168.\r\n[5]\tSchubert, K., W. Bier, W. Keller, G. Linder and D. Seidel; \"Gas to Gas Heat Transfer in Micro Heat Exchangers,\u201d Chem. Eng. Process., 32, 1993, pp.33-43.\r\n[6]\tSuga, S., A. Nagaki and J. Yoshida; \"Highly Selective Friedel\uf02dCrafts Monoalkylation Using Micromixing,\u201d Chem. Commun., 3, 2003, pp.354-355.\r\n[7]\tTaghavi-Moghadam, S., A. Kleemann and K. G. Golbig; \"Microreaction Technology as a Novel Approach to Drug Design, Process Development and Reliability,\u201d Org. Process. Res. Dev., 5, 2001, pp.652-658.\r\n[8]\tFukuyama, T., M. Shinmen, S. Nishitani, M. Sato and I. Ryu; \"A Copper-Free Sonogashira Coupling Reaction in Ionic Liquids and its Application to a Microflow System for Efficient Catalyst Recycling,\u201d Org. Lett., 4, 2002, pp.1691-1694.\r\n[9]\tYoshida, J. ed.; Microreactors, Epoch-making Technology for Synthesis (Maikuroriakuta, Shinjidai no Gouseigijutsu), CMC Publishing Co., Ltd., Tokyo, Japan, 2003.\r\n[10]\tMatsushita, Y., T. Ichimura, N. Ohba, S. Kumada, K. Sakeda, T. Suzuki, H. Tanibata and T. Murata; \"Recent Progress on Photoreactions in Microreactors,\u201d Pure Appl. Chem., 79, 2007, pp.1959-1968.\r\n[11]\tLu, H., M. A. Schmidt and K. F. Jensen; \"Photochemical Reactions and On-Line UV Detection in Microfabricated Reactors,\u201d Lab Chip, 1, 2001, pp.22-28.\r\n[12]\tUeno, K., F. Kitagawa and N. Kitamura; \"Photocyanation of Pyrene across and Oil\/Water Interface in a Polymer Microchannel Chip,\u201d Lab Chip, 2, 2002, pp.231-234.\r\n[13]\tGorges, R., S. Meyer and G. Kerisel; \"Photocatalysis in Microreactors,\u201d J. Photochem. Photobiol. A, 167, 2004, pp.95-99.\r\n[14]\tFukuyama, T., Y. Hino, N. Kamata and I. Ryu; \"Quick Execution of [2+2] Type Photochemical Cycloaddition Reaction by Continuous Flow System Using a Glass-made Microreactor,\u201d Chem. Lett., 33, 2004, pp.1430-1431.\r\n[15]\tFukuyama, T., Y. Kajihara, Y. Hino and I. Ryu; \"Continuous Microflow [2+2] Photocycloaddition Reactions Using Energy-Saving Compact Light Sources,\u201d J. Flow Chem., 1, 2011, pp.40-45.\r\n[16]\tMaeda, H., H. Mukae and K. Mizuno; \"Enhanced Efficiency and Regioselectivity of Intramolecular [2+2] Photocycloaddition of 1-Cyanonaphthalene Derivative Using Microreactors,\u201d Chem. Lett., 34, 2005, pp.66-67.\r\n[17]\tSugimoto, A., T. Fukuyama, Y. Sumino, M. Takagi and I. Ryu;\"Microflow Photo-Radical Reaction Using a Compact Light Source: Application to the Barton Reaction Leading to a Key Intermediate for Myriceric Acid A,\u201d Tetrahedron, 65, 2009, pp.1593-1598.\r\n[18]\tPitts, J. N., Jr., R. L. Letsinger, R. P. Taylor, J. M. Patterson, G. Reckten wald and R. B. Martin; \"Photochemical Reactions ofBenzophenone in Alcohols,\u201d J. Am. Chem. Soc., 81, 1958, pp.1068-1077.\r\n[19]\tLu, H., M. A. Schmidt and K. F. Jensen; \"Photochemical Reactions and On-Line UV Detection in Microfabricated Reactors,\u201d Lab Chip, 1, 2001, pp.22-28.\r\n","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 92, 2014"}