Amr A. Fouad and Waleed H. Albuali and Iyad Jresat
Protective Effect of Hesperidin against Cyclophosphamide Hepatotoxicity in Rats
730 - 733
2014
8
7
International Journal of Bioengineering and Life Sciences
https://publications.waset.org/pdf/9998864
https://publications.waset.org/vol/91
World Academy of Science, Engineering and Technology
The protective effect of hesperidin was investigated in
rats exposed to liver injury induced by a single intraperitoneal
injection of cyclophosphamide (CYP) at a dose of 150 mg kg1.
Hesperidin treatment (100 mg kg1day, orally) was applied for seven
days, starting five days before CYP administration. Hesperidin
significantly decreased the CYPinduced elevations of serum alanine
aminotransferase, and hepatic malondialdehyde and myeloperoxidase
activity, significantly prevented the depletion of hepatic glutathione
peroxidase activity resulted from CYP administration. Also,
hesperidin ameliorated the CYPinduced liver tissue injury observed
by histopathological examination. In addition, hesperidin decreased
the CYPinduced expression of inducible nitric oxide synthase, tumor
necrosis factorα, cyclooxygenase2, Fas ligand, and caspase9 in
liver tissue. It was concluded that hesperidin may represent a
potential candidate to protect against CYPinduced hepatotoxicity.
Open Science Index 91, 2014