Evaluation of Salivary Nickel Level during Orthodontic Treatment
Since nickel is a known toxic and carcinogenic metal, the present study was designed to evaluate the level of nickel released into the saliva of orthodontic patients. Non-stimulated saliva was collected from 18 patients attending The Orthodontic Clinic of Dental Faculty of Benghazi University. Patients were divided into two groups and level of nickel was determined by atomic absorption spectrophotometry. Nickel concentration value (mg/L) in first group prior to starting treatment was 0.097± 0.071. An increase in level of nickel was followed by decrease 4 and 8 weeks after applying the arch wire (0.208± 0.112) and (0.077±0.056 mg/L) respectively. Nickel levels in saliva of the second group were showed minimal variation and ranged from 0.061± 0.044mg/L to 0.083±0.054 throughout period of study. It may be concluded that there could be a release of nickel from the appliances used in first group but it doesn't reach toxic level in saliva.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1091128Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1997
 Das K K, Das S N, and Dhundasi S A. Nickel, Its Adverse Health Effects & Oxidative Stress. Indian J Med Res. 2008; 412-425.
 Fors R, and Persson M. Nickel in Dental Plaque and Saliva in Patients with and without Orthodontic Appliances. European Journal of Orthodontics. 2006; 28: 292-297.
 Ağaoğlu G, Arun T, Izgϋ B, and Yarat A. Nickel and Chromium Levels in the Saliva and Serum of Patients with Fixed Orthodontic Appliances. Angle Orthodontist. 2001; 71(No 5): 375-379.
 Menezes LM, Quintäo CA, and Bolognese AM. Urinary excretion levels of nickel in orthodontic patients. American Journal of Orthodontics and Dentofacial Orthopedics. 2007; 635-638.
 Gjerdet NR, Hero H. Metal Release from Heat-Treated Orthodontic Arch Wires. Acta Odontol Scan. 1987; 45:409–14.
 Petoumeno E, Kislyuk M, Hoederth H, Keilig L, Bourauel C, and Jäger A. Corrosion Susceptibility and Nickel Release of Nickel Titanium Wires During Clinical Application. Journal of Orofacial Orthopedics. 2008; 69:411-23.
 Gursoy UK, Sokucu O, Uitto V, Aydin A, Demirer S, Toker H, Erdem E and Sayal A. The Role of Nickel Accumulation and Epithelial Cell Proliferation in Orthodontic Treatment- Induced Gingival Overgrowth. European Journal of Orthodontics. 2007; 29: 555-558.
 Moore PD, Chapman SB Methods in plant ecology. Blackwell Scientific Publication, Oxford, London 1986
 Jia W, Beatty MW, Reinhart DM, Petro TM, Cohen DM, Maze CR, Strom EA, Hoffman M. Nickel Release from Orthodontic Arch Wires and Cellular Immune Response to Various Nickel Concentrations. Journal of Biomedical Materials Research. 1999; 48:488-495
 Ramadan AA. Effect of Nickel and Chromium on Gingival Tissues Duuring Orthodontic Treatment: Longituinal Study World J Orthod. 2004;.5:230-235.
 Kerosuo H, Kanerva L. Systemic Contact Dermatitis Caused by Nickel in a Stainless Steel Orthodontic Appliance. Contact Dermatitis. 1997; 36:112–3.
 Temesvari E, Racz I.Nickel Sensitivity from Dental Prosthesis. Contact Dermatitis. 1988; 18:50-1.
 Rahilly G, Price N. Nickel Allergy and Orthodontics. J Orthod. 2003; 30:171-174.