TY - JFULL AU - Amr A. Fouad and Waleed H. Albuali and Iyad Jresat PY - 2014/3/ TI - Protective Effect of Thymoquinone against Arsenic-Induced Testicular Toxicity in Rats T2 - International Journal of Pharmacological and Pharmaceutical Sciences SP - 97 EP - 101 VL - 8 SN - 1307-6892 UR - https://publications.waset.org/pdf/9997417 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 86, 2014 N2 - The protective effect of thymoquinone (TQ) was investigated in rats exposed to testicular injury induced by sodium arsenite (10mg/kg/day, orally, for two days). TQ treatment (10mg/kg/day, intraperitoneal injection) was applied for five days, starting three day before arsenic administration. TQ significantly attenuated the arsenic-induced decreases of serum testosterone, and testicular reduced glutathione level, and significantly decreased the elevations of testicular malondialdehyde and nitric oxide levels resulted from arsenic administration. Also, TQ ameliorated the arsenic-induced testicular tissue injury observed by histopathological examination. In addition, TQ decreased the arsenic-induced expression of inducible nitric oxide synthase and caspase-3 in testicular tissue. It was concluded that TQ may represent a potential candidate to protect against arsenic-induced testicular injury.  ER -