TY - JFULL AU - Y. Sangsen and K. Likhitwitayawuid and B. Sritularak and K. Wiwattanawongsa and R. Wiwattanapatapee PY - 2013/1/ TI - Novel Solid Lipid Nanoparticles for Oral Delivery of Oxyresveratrol: Effect of the Formulation Parameters on the Physicochemical Properties and in vitro Release T2 - International Journal of Pharmacological and Pharmaceutical Sciences SP - 876 EP - 884 VL - 7 SN - 1307-6892 UR - https://publications.waset.org/pdf/9996796 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 84, 2013 N2 - Novel solid lipid nanoparticles (SLNs) were developed to improve oral bioavailability of oxyresveratrol (OXY). The SLNs were prepared by a high speed homogenization technique, at an effective speed and time, using Compritol® 888 ATO (5% w/w) as the solid lipid. The appropriate weight proportions (0.3% w/w) of OXY affected the physicochemical properties of blank SLNs. The effects of surfactant types on the properties of the formulations such as particle size and entrapment efficacy were also investigated. Conclusively, Tween 80 combined with soy lecithin was the most appropriate surfactant to stabilize OXY-loaded SLNs. The mean particle size of the optimized formulation was 134.40 ± 0.57 nm. In vitro drug release study, the selected S2 formulation showed a retarded release profile for OXY with no initial burst release compared to OXY suspension in the simulated gastrointestinal fluids. Therefore, these SLNs could provide a suitable system to develop for the oral OXY delivery. ER -