@article{(Open Science Index):https://publications.waset.org/pdf/9625,
	  title     = {Function of miR-125b in Zebrafish Neurogenesis},
	  author    = {Minh T. N. Le and  Cathleen Teh and  Ng Shyh-Chang and  Vladimir Korzh and  Harvey F. Lodish and  Bing Lim},
	  country	= {},
	  institution	= {},
	  abstract     = {MicroRNAs are an important class of gene expression
regulators that are involved in many biological processes including
embryogenesis. miR-125b is a conserved microRNA that is enriched
in the nervous system. We have previously reported the function of
miR-125b in neuronal differentiation of human cell lines. We also
discovered the function of miR-125b in regulating p53 in human and
zebrafish. Here we further characterize the brain defects in zebrafish
embryos injected with morpholinos against miR-125b. Our data
confirm the essential role of miR-125b in brain morphogenesis
particularly in maintaining the balance between proliferation, cell
death and differentiation. We identified lunatic fringe (lfng) as an
additional target of miR-125b in human and zebrafish and suggest
that lfng may mediate the function of miR-125b in neurogenesis.
Together, this report reveals new insights into the function of miR-
125b during neural development of zebrafish.},
	    journal   = {International Journal of Bioengineering and Life Sciences},
	  volume    = {4},
	  number    = {2},
	  year      = {2010},
	  pages     = {156 - 161},
	  ee        = {https://publications.waset.org/pdf/9625},
	  url   	= {https://publications.waset.org/vol/38},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 38, 2010},
	}