@article{(Open Science Index):https://publications.waset.org/pdf/8288,
	  title     = {Interactions between Cells and Nanoscale Surfaces of Oxidized Silicon Substrates},
	  author    = {Chung-Yao Yang and  Lin-Ya Huang and  Tang-Long Shen and  J. Andrew Yeh},
	  country	= {},
	  institution	= {},
	  abstract     = {The importance for manipulating an incorporated
scaffold and directing cell behaviors is well appreciated for tissue
engineering. Here, we developed newly nano-topographic oxidized
silicon nanosponges capable of being various chemical modifications
to provide much insight into the fundamental biology of how cells
interact with their surrounding environment in vitro. A wet etching
technique is exerted to allow us fabricated the silicon nanosponges in a
high-throughput manner. Furthermore, various organo-silane
chemicals enabled self-assembled on the surfaces by vapor deposition.
We have found that Chinese hamster ovary (CHO) cells displayed
certain distinguishable morphogenesis, adherent responses, and
biochemical properties while cultured on these chemical modified
nano-topographic structures in compared with the planar oxidized
silicon counterparts, indicating that cell behaviors can be influenced
by certain physical characteristic derived from nano-topography in
addition to the hydrophobicity of contact surfaces crucial for cell
adhesion and spreading. Of particular, there were predominant
nano-actin punches and slender protrusions formed while cells were
cultured on the nano-topographic structures. This study shed potential
applications of these nano-topographic biomaterials for controlling
cell development in tissue engineering or basic cell biology research.},
	    journal   = {International Journal of Biotechnology and Bioengineering},
	  volume    = {5},
	  number    = {4},
	  year      = {2011},
	  pages     = {197 - 203},
	  ee        = {https://publications.waset.org/pdf/8288},
	  url   	= {https://publications.waset.org/vol/52},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 52, 2011},
	}