@article{(Open Science Index):https://publications.waset.org/pdf/8261, title = {Optimization of Gentamicin Production: Comparison of ANN and RSM Techniques}, author = {M.Rajasimman and S.Subathra}, country = {}, institution = {}, abstract = {In this work, statistical experimental design was applied for the optimization of medium constituents for Gentamicin production by Micromsonospora echinospora subs pallida (MTCC 708) in a batch reactor and the results are compared with the ANN predicted values. By central composite design, 50 experiments are carried out for five test variables: Starch, Soya bean meal, K2HPO4, CaCO3 and FeSO4. The optimum condition was found to be: Starch (8.9,g/L), Soya bean meal (3.3 g/L), K2HPO4 (0.8 g/L), CaCO3 (4 g/L) and FeSO4 (0.03 g/L). At these optimized conditions, the yield of gentamicin was found to be 1020 mg/L. The R2 values were found to be 1 for ANN training set, 0.9953 for ANN test set, and 0.9286 for RSM.}, journal = {International Journal of Chemical and Molecular Engineering}, volume = {3}, number = {3}, year = {2009}, pages = {163 - 168}, ee = {https://publications.waset.org/pdf/8261}, url = {https://publications.waset.org/vol/27}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 27, 2009}, }