WASET
	@article{(Open Science Index):https://publications.waset.org/pdf/8247,
	  title     = {High Glucose Increases Acetylcholine-Induced Ca2+ Entry and Protein Expression of STIM1},
	  author    = {Hong Ding and  Fatiha Benslimane and  Isra Marei and  Chris R. Triggle},
	  country	= {},
	  institution	= {},
	  abstract     = {Hyperglycaemia is a key factor that contributes to the
development of diabetes-related microvascular disease and a major
risk factor for endothelial dysfunction. In the current study, we have
explored glucose-induced abnormal intracellular calcium (Ca2+
i)
homeostasis in mouse microvessel endothelial cells (MMECs) in
high glucose (HG) (40mmol/L) versus control (low glucose, LG) (11
mmol/L). We demonstrated that the exposure of MMECs to HG for 3
days did not change basal Ca2+
i, however, there was a significant
increase of acetylcholine-induced Ca2+ entry. Western blots
illustrated that exposure to HG also increased STIM1 (Stromal
Interaction Molecule 1), but not Orai1 (the pore forming subunit),
protein expression levels. Although the link between HG-induced
changes in STIM1 expression, enhanced Ca2+ entry and endothelial
dysfunction requires further study, the current data are suggestive
that targeting these pathways may reduce the impact of HG on
endothelial function.},
	    journal   = {International Journal of Pharmacological and Pharmaceutical Sciences},
	  volume    = {6},
	  number    = {4},
	  year      = {2012},
	  pages     = {67 - 70},
	  ee        = {https://publications.waset.org/pdf/8247},
	  url   	= {https://publications.waset.org/vol/64},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 64, 2012},
	}