The Key Role of the Steroidal Hormones in the Pattern Distribution of the Epiphyseal Structure in Rabbit

Authors: Fatahian Dehkordi R.F, Parchami A.

Abstract:

Steroidal hormones with the efficient changes on the epiphyseal growth plate may influence tissue structure properties. Presents paper to investigate the effects of gonadectomy in the pattern distribution of the epiphyseal structure. Fifteen adult female New Zealand white rabbits were separated into three groups. One group was intact and others groups were selected for surgical operation. From these two groups, one group carried out steroidal administration. The results obtained showed that there is no statistically difference in the mean diameter of the growth plate cells between all three groups. The maximum value of the cartilage cells were allocated to the gonadectomized group and the minimum number were observed in Hormonal induced group significantly. Growth plate height was significantly greater in gonadectomized group than in two other groups.

Keywords: Steroidal hormones, Ovariectomy, Rabbit, Epiphyseal structure

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1070215

References:

[1] O. T. Gray, "Estrogens and the skeleton: Cellular and molecular mechanisms," J. Steroid. Biochem., vol. 34, p. 285, 1989.
[2] M. M. Grumbach, and R. J. Auchus, "Estrogen: consequences and implications of human mutations in synthesis and action," J. Clin. Endocrinol. Metab., vol. 84, pp. 4677-4694, 1999.
[3] D. F. Gunther, A. S. Calikoglu, and L. E. Underwood, "The effects of the estrogen receptor blocker, Faslodex (ICI 182, 780), on estrogen-accelerated bone maturation in mice," Pediatr. Res., vol. 46, pp. 269-273, 1999.
[4] T. M. Hering, "Regulation of chondrocyte gene expression," Front. Biosci., vol. 4, pp. 743-761, 1999.
[5] H. M. Kronenberg, "Development regulation of the growth plate," Nature, vol. 423, pp. 332-336, 2003.
[6] G. Kuiper, E. Enmark, and M. Pelto-Huikko, "Cloning of a novel estrogen receptor expressed in rat prostate and ovary," Proc. Natl. Acad. Sci., vol. 93, p. 5925, 1996.
[7] E. Nasatzky, Z. Schwartz, and B. D. Boyan, "Sex-dependent effect of 17-beta-estradiol on chondrocyte differentiation in culture," J. Cell. Physiol., vol. 154, p. 359, 1994.
[8] L. Nisson, A. Boman, and L. Sävendahl, "Demonstration of estrogen receptor- immunoreactivity in human growth plate cartilige," J. Clin. Endocrinol. Metab., vol. 84, p. 370, 1999.
[9] O. Nilsson, R. Marino, F. De Luca, M. Phillip, and J. Baron, "Endocrine Regulation of the Growth Plate," Horm. Res., vol. 64, pp. 157-165, 2005.
[10] E. P. Smith, J. Boyd, G. R. Frank, H. Takahashi, R. M. Cohen, B. Specker, T. C. Williams, D. B. Lubahn, K. S. Korach, "Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man," N. Engl. J. Med., vol. 3331, pp. 1056-1061, 19994.
[11] D. A. Stevens, and G. R. Williams, "Hormone regulation of chondrocyte differentiation and endochronal bone formation," Mol. Cell. Endocrinol., vol. 151, pp. 195-204, 1999.
[12] R. M. Talwar, B. S. Wong, K. Svoboda, and R. P. Harper, "Effects of estrogen on chodrocyte proliferation and collagen synthesis in skeletally mature articular cartilage," J. Oral. Maxillofac. Surg., vol. 64(4), pp. 600-9, 2006.
[13] M. Takahasi, and T. Noumura, "Sexually dimorphic and laterally asymmetric development of the embryonic duck syrinx: Effects of estrogen on in vivo cell proliferaiton and chondrogenesis," Dev. Biol., vol. 121, p. 417, 1987.
[14] M. Weise, S. De-Levi, K. M. Barnes, R. I. Gafni, C. Abad and J. Baron, "Effects of estrogen on growth plate senescence and epiphyseal fusion", PNAS., vol. 98(12), pp. 6871-6876, 2001.
[15] S. Wickman, I. Sipila, C. Ankarberg-Lindgren, E. Norjovaara, and L. Dunkel "A specific aromatase inhibitor and potential increase in adult height in boys with delayed puberty: a randomized controlled trial," Lancet, vol. 357, pp. 1743-1748, 2001.