@article{(Open Science Index):https://publications.waset.org/pdf/7704,
	  title     = {Topical Delivery of Thymidine Dinucleotide to Induce p53 Generation in the Skin by Elastic Liposome},
	  author    = {Yi-Ping Fang and  Yi-Ting Wong},
	  country	= {},
	  institution	= {},
	  abstract     = {Transcription factor p53 has a powerful tumor
suppressing function that is associated with many cancers. However,
p53 of the molecular weight was higher make the limitation across to
skin or cell membrane. Thymidine dinucleotide (pTT), an
oligonucleotide, can activate the p53 transcription factor. pTT is a
hydrophilic and negative charge oligonucleotide, which delivery in to
cell membrane need an appropriate carrier. The aim of this study was
to improve the bioavailability of the nucleotide fragment, thymidine
dinucleotide (pTT), using elasic liposome carriers to deliver the drug
into the skin. The study demonstrate that dioleoylphosphocholine
(DOPC) incorporated with sodium cholate at molar ratio 1:1 can
archived the particle size about 220 nm. This elastic liposome could
penetration through skin from stratum corneum to whole epidermis by
confocal laser scanning microscopy (CLSM). Moreover, we observed
the the slight increase in generation of p53 by western blot.},
	    journal   = {International Journal of Biotechnology and Bioengineering},
	  volume    = {6},
	  number    = {6},
	  year      = {2012},
	  pages     = {381 - 384},
	  ee        = {https://publications.waset.org/pdf/7704},
	  url   	= {https://publications.waset.org/vol/66},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 66, 2012},
	}