Evaluation of Some Prominent Biomarkers in Rural Type – 2 Diabetes Mellitus Cases in Kanyakumari District, Tamil Nadu, India
Commenced in January 2007
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Evaluation of Some Prominent Biomarkers in Rural Type – 2 Diabetes Mellitus Cases in Kanyakumari District, Tamil Nadu, India

Authors: Murugan. A., Jerlin Nirmala. F .

Abstract:

Life is beautiful. But, it is decided by genes, environment and the individual and shattered by the natural and / or the invited problems. Most of the global rural helpless masses are struggling for their survival since; they are neglected in all aspects of life including health. Amidst a countless number of miserable diseases in man, diabetes is becoming a dreaded killer and ramifying the entire globe in a jet speed. Diabetes control continues as a Herculean task to the scientific community and the modern society in the 21st century also. T2DM is not pertaining to any age and it can develop even during the childhood. This multifactorial disease abruptly changes the activities of certain vital biomarkers in the present rural T2DM cases. A remarkable variation in the levels of biomarkers like AST, ALT, GGT, ALP, LDH, HbA1C, C- peptide, fasting sugar, post-prandial sugar, sodium, potassium, BUN, creatinine and insulin show the rampant nature of T2DM in this physically active rural agrarian community.

Keywords: Alanine aminotransferase, Aspartate aminotransferase, Blood urea nitrogen, Glycated haemoglobin, Thyroid stimulating hormone

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1332514

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References:


[1] M. M. Huizinga and R. L. Rothman, "Addressing the diabetes pandemic: A comprehensive approach", Ind. J. Med. Res, Vol (124), 2006, pp. 481 - 84.
[2] S. Wild, G. Roglic, A. Green, R. Sicree and H. King, "Global prevalence of diabetes: Estimates for the year 2000 and projections for 2030," Diabetes care, Vol (27), 2004, pp.1047 - 53.
[3] S. O-Rahilly, "Non-insulin dependent diabetes mellitus: the gathering storm", BMJ, Vol (314), 1997, pp. 955 - 59.
[4] J.C. Alcolado and R, Alcolado, " Importance of maternal history of non-insulin dependent diabetic patients", BMJ, Vol (302), 1991, 99. 1178 - 80.
[5] W. Bao, S.R. Srinivasan, W.A. Wattigney and G.S. Berenson, "The relation of parental cardiovascular disease to risk factors in children and young adults: the Bongalusa Heart Study", Circulation, Vol (91), 1995, PP.365 - 71.
[6] M.A. Charles, D.J. Pettitt, R.L. Hanson, P.H. Bennett, M.F. Saad, Q.Z. Liu and W.C. Knowler, "Familial and metabolic factors related to blood pressure in Pima Indian Children", A.J. Epidemiol, Vol (140), 1994, PP. 123 - 31.
[7] S. Tsimikas, J. Willerson and P. Ridker, "CRP and other emerging biomarkers to optimize risk of stratification of vulnerable patients", J. Am. Coll. Cardiol, Vol (47), 2006, PP. C-19, C-31.
[8] www.en.wikipedia.org/wiki/kanyakumari_district
[9] E.Thurston and K. Rengachari, "Asian Educational Society, New Delhi", 1993, PP. 361 - 89.
[10] 77 Electronica Ltd, 1116 Budapest, Hungary.
[11] P.C. Kao, R. L. Taylor and F.C. Service, "Proinsulin by immunochemiluminometric assay for the diagnosis of insulinoma", J. Clin. Endocrinol. Metab, Vol (78), 1994, PP. 1048 - 51.
[12] P. Trinder, "Blood safety and clinical technology, Guidelines on standard operating procedures for clinical chemistry", Ann.Clin.Biochem, Vol (6), 1969, PP.24.
[13] M. Rendell, "C-peptide levels as a criterian in treatment of maturity onset diabetes", J. Clin.Endocrinol.Metab, Vol 57 (6), 1983, PP.1198.
[14] L. Bry, P.C. Chen and D.B.Sacks, "Effects of haemoglobin variants and chemically modified derivatives on assays for glycohaemoglobin", Clin.Chem, Vol (47), 2001, PP.153 - 63.
[15] "Expert Panel of the IFCC on enzymes", Clin.Chem.Acta, Vol (70), 1976, F 19.
[16] D.W. Bradley, J.E. Maynard, G. Emery and H. Webster, "Transaminase activites in serum long-term hemodialysis patients", Clin. Chem, Vol 18 (12), 1972, PP. 1442.
[17] G.Szasz, "Methods of enzymatic analysis", 2 cde edn 2, 1974, PP. 715.
[18] A.M. Johnson, E.M. Rohlfs and L.M. Silverman, In : N.W. Tietz, "Text Book of Clinical Chemistry" (3rd edn), C.A. Burtis and E.R. Ashwood (edn), W.B. Saunders, Philadelphia, 1999, PP. 477 - 540, 676 - 689.
[19] P. Moss and A.R. Henderson, In: "Clinical Enzymology", (3rd edn), W.B. Saunders, Philadelphia, 1999, PP. 617 - 721.
[20] D. Young, In: "Effect of preanalytical variables on clinical laboratory tests" (2nd edn), AACC Press, Washington, 1997, PP. 4 - 489.
[21] D.S. Young, In: "Effects of drugs on clinical laboratory tests" (3rd edn), AACC press, Washington, 1990, PP. 21:5.
[22] M.S. Frant, "History of the early commercialization of ion selective electrodes", Analyst, Vol (119), 1994, PP. 2293-301.
[23] P. Trinder, "A rapid method for the determination of sodium in serum," Analyst, Vol (76), 1951, P - 596.
[24] www.tekisimizanaliz.com
[25] H. King, R.E. Aubert and W.H. Herman,"Global burdon of diabetes, 1995 - 2025 : prevalence, numerical estimates and projections," Diabetes Care, Vol (21), 1998, PP. 481 - 84.
[26] P.K. Zimmet, K.G. Albert and J. Shaw, "Global and societal implications of the diabetes epidemic," Nature, Vol (414), 2001, PP. 782 - 87.
[27] L.M. Tierney, S.J. McPhee and M.A. Papadakis, In : "Current medical diagnosis and treatment". International edition, Lange Medical Books, McGraw Hill, New York, 2002, PP. 1203 - 15.
[28] C.N. Hales and D.J.P.Parker, "T2DM : the thrifty phenotype hypothesis", Diabetologia, Vol 35 (7), 1992, PP.595 - 601.
[29] N.D. Neufeld, L.J. Raffel, C. Landon, Y.D. Chen, and C.M. Vadheim, "Early presentation of type - 2 diabetes in Mexican - American Youth", Diabetes care, Vol 21 (1), 1998, PP. 80-6.
[30] A.D. Sniderman, R. Bhopal, D. Prabhakan, N. Sarrafzadegan and A. Tchernof, "Why might South Asians be so susceptible to central obesity and its atherogenic consequences ? The adipose tissue overflow hypothesis", International J.Epidemiol, Vol 36 (1), 2007, PP. 220 - 25.
[31] S. Genuth, "Insights from the diabetes control and complications trial / epidemiology of diabetes interventions and complications study on the use of intensive glycaemic treatment to reduce the risk of complications of Type - 1 diabetes", Endocr. Pract, Vol 12 (Suppl : 1), 2006, PP. 34 - 41.
[32] E. H. Harris, "Elevated liver function tests in Type 2 diabetes", Clin. Diabet, Vol 23 (3) : 115 - 19.
[33] www.wikipedia.org/wiki/Aspartate_transaminase
[34] H.Li-Fern and C. Rajasoorya, "The elevated serum ALP - the chase that led to two endocrinopathies and one possible unifying diagnosis", Eur.J. Endocrinol, Vol 140 (2), 1999, PP. 143 - 7.
[35] M.G. Betro, R.C.Oon and J.B. Edwards, "Gamma Glutamyl transpeptidase in diseases of the liver and bone", Am. J. Clinic.Pathol, Vol 60 (5), 1973, PP.672 - 78.
[36] www.wikipedia.org/wiki/Lactate_dehydrogenase
[37] www.nlm.nih.gov/medlineplus/ency/article/003473.htm
[38] W.J.Johnson, W.W. Hagge, R.D. Wagoner, R.P.Dinapoli and J.W. Rosevear, "Effects of urea loading in patients with for advanced renal failure", Myoclin.Proc, Vol 47 (1), 1972, PP. 27 - 29.
[39] T.P. Singh, A.D. Singh and T.B. Singh, "Prevalence of D.mellitus in Manipur", In : S.K. Shah (editor). Diabetes update: Guwahati, North Eastern Diabetes Society, 2001, PP. 13 - 19.
[40] R. Chatterjee, H.C. Yeh, T. Shafi, E. Selvin, C. Anderson, J.S. Pankow, E. Miller and F. Brancati F, "Serum and dietary potassium and risk of incident of T2DM : The Atherosclerosis Risk in Community (ARIC) Study", Arch.Intern.Med, Vol 170 (19), 2010, PP. 1745 - 51