C. De Lazzari and E. Del Prete and I. Genuini and F. Fedele
Computational Study on CardiacCoronary Interaction in Terms of Coronary FlowPressure Waveforms in Presence of Drugs Comparison Between Simulated and In Vivo Data
401 - 405
2012
6
8
International Journal of Biomedical and Biological Engineering
https://publications.waset.org/pdf/6571
https://publications.waset.org/vol/68
World Academy of Science, Engineering and Technology
Cardiovascular human simulator can be a useful tool
in understanding complex physiopathological process in
cardiocirculatory system. It can also be a useful tool in order to
investigate the effects of different drugs on hemodynamic
parameters. The aim of this work is to test the potentiality of our
cardiovascular numerical simulator CARDIOSIM© in reproducing
flowpressure coronary waveforms in presence of two different
drugs Amlodipine (AMLO) and Adenosine (ADO). In particular a
timevarying intramyocardial compression, assumed to be
proportional to the left ventricular pressure, was related to the venous
coronary compliances in order to study its effects on the coronary
blood flow and the flowpressure loop. Considering that coronary
circulation dynamics is strongly interrelated with the mechanics of
the left ventricular contraction, relaxation, and filling, the numerical
model allowed to analyze the effects induced by the left ventricular
pressure on the coronary flow.
Open Science Index 68, 2012