Amaneh Javid and Shahin Ahmadian and Ali A. Saboury and Saeed Rezaei-Zarchi
Anticancer Effect of Doxorubicin Loaded Heparin based Superparamagnetic Iron oxide Nanoparticles against the Human Ovarian Cancer Cells
41 - 45
2011
5
2
International Journal of Biomedical and Biological Engineering
https://publications.waset.org/pdf/560
https://publications.waset.org/vol/50
World Academy of Science, Engineering and Technology
This study determines the effect of naked and heparinbased
superparamagnetic iron oxide nanoparticles on the human
cancer cell lines of A2780. Doxorubicin was used as the anticancer
drug, entrapped in the SPIONPs. This study aimed to decorate
nanoparticles with heparin, a molecular ligand for &039;active&039; targeting
of cancerous cells and the application of modifiednanoparticles in
cancer treatment. The nanoparticles containing the anticancer drug
DOX were prepared by a solvent evaporation and emulsification
crosslinking method. The physicochemical properties of the
nanoparticles were characterized by various techniques, and uniform
nanoparticles with an average particle size of 110±15 nm with high
encapsulation efficiencies (EE) were obtained. Additionally, a
sustained release of DOX from the SPIONPs was successful.
Cytotoxicity tests showed that the SPIODOXHP had higher cell
toxicity than the individual HP and confocal microscopy analysis
confirmed excellent cellular uptake efficiency. These results indicate
that HP based SPIONPs have potential uses as anticancer drug
carriers and also have an enhanced anticancer effect.
Open Science Index 50, 2011