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Flow Visualization and Characterization of an Artery Model with Stenosis

Authors: Anis S. Shuib, Peter R. Hoskins, William J. Easson


Cardiovascular diseases, principally atherosclerosis, are responsible for 30% of world deaths. Atherosclerosis is due to the formation of plaque. The fatty plaque may be at risk of rupture, leading typically to stroke and heart attack. The plaque is usually associated with a high degree of lumen reduction, called a stenosis.It is increasingly recognized that the initiation and progression of disease and the occurrence of clinical events is a complex interplay between the local biomechanical environment and the local vascular biology. The aim of this study is to investigate the flow behavior through a stenosed artery. A physical experiment was performed using an artery model and blood analogue fluid. An axisymmetric model constructed consists of contraction and expansion region that follow a mathematical form of cosine function. A 30% diameter reduction was used in this study. The flow field was measured using particle image velocimetry (PIV). Spherical particles with 20μm diameter were seeded in a water-glycerol-NaCl mixture. Steady flow Reynolds numbers are 250. The area of interest is the region after the stenosis where the flow separation occurs. The velocity field was measured and the velocity gradient was investigated. There was high particle concentration in the recirculation zone. High velocity gradient formed immediately after the stenosis throat created a lift force that enhanced particle migration to the flow separation area.

Keywords: Biofluid Mechanics, PIV, Stenosis artery

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[1] C. G. Caro, J. M. Fitz-Gerald, and R. C. Schroter, "Atheroma and arterial wall shear. Observation, correlation and proposal of a shear dependent mass transfer mechanism for atherogenesis," Proc Royal Soc Lond Biol Sci, vol. 177, pp. 109-159, 1971.
[2] D. N. Ku, "Blood flow in arteries," Annual Review Of Fluid Mechanics, vol. 29, pp. 399-434, 1997.
[3] J. J. Hathcock, "Flow effects on coagulation and thrombosis," Arteriosclerosis Thrombosis and Vascular Biology, vol. 26, no. 8, pp. 1729-1737, Aug, 2006.
[4] D. P. Giddens, C. K. Zarins, and S. Glagov, "The Role Of Fluid- Mechanics In The Localization And Detection Of Atherosclerosis," Journal Of Biomechanical Engineering-Transactions Of The Asme, vol. 115, no. 4, pp. 588-594, Nov, 1993.
[5] M. D. Deshpande, and D. P. Giddens, "Turbulence Measurements in a Constricted Tube," Journal of Fluid Mechanics, vol. 97, no. MAR, pp. 65-89, 1980.
[6] S. A. Ahmed, and D. P. Giddens, "Velocity-Measurements in Steady Flow through Axisymmetric Stenoses at Moderate Reynolds-Numbers," Journal of Biomechanics, vol. 16, no. 7, pp. 505-&, 1983.
[7] C. G. Caro, The mechanics of the circulation, Oxford: Oxford University Press, 1978.
[8] Q. Long, X. Y. Xu, K. V. Ramnarine et al., "Numerical investigation of physiologically realistic pulsatile flow through arterial stenosis," Journal of Biomechanics, vol. 34, no. 10, pp. 1229-1242, 2001.
[9] A. Shuib, P. Hoskins, and W. Easson, "Experimental investigation of particle distribution in a flow through a stenosed artery," Journal of Mechanical Science and Technology, vol. 25, no. 2, pp. 357-364, 2010.
[10] J. R. Blake, W. J. Easson, and P. R. Hoskins, "A Dual-Phantom System for Validation of Velocity Measurements in Stenosis Models Under Steady Flow," Ultrasound in Medicine & Biology, vol. 35, no. 9, pp. 1510-1524, 2009.
[11] S. A. Berger, and L. D. Jou, "Flows in stenotic vessels," Annual Review of Fluid Mechanics, vol. 32, pp. 347-382, 2000.
[12] D. M. Wootton, and D. N. Ku, “Fluid mechanics of vascular systems, diseases, and thrombosis,” Annual Review Of Biomedical Engineering, vol. 1, pp. 299-329, 1999.