Rizna Triana Dewi and Sanro Tachibana and Ahmad Darmawan
Antidiabetic and Antioxidative Activities of Butyrolactone I from Aspergillus terreus MC751
929 - 934
2012
6
10
International Journal of Biotechnology and Bioengineering
https://publications.waset.org/pdf/5182
https://publications.waset.org/vol/70
World Academy of Science, Engineering and Technology
The bioassayguided isolation and purification of an
ethyl acetate extract of Aspergillus terreus MC751 led to the
characterization of butyrolactone I as an antidiabetic and antioxidant.
The antidiabetic activity of butyrolactone I was evaluated by α
glucosidase and αamylase inhibition assays. Butyrolactone I
demonstrated significant concentrationdependent, mixedtype
inhibitory activity against yeast αglucosidase with an IC50 of 54μM.
However, the compound exhibited less activity against rat intestinal
αglucosidase and αamylase. This is the first report on αglucosidase
inhibitory activity of butyrolactone I. The antioxidative activity of
butyrolactone I was evaluated based on scavenging effects on 1,1
diphenyl2picrylhydrazyl (DPPH) (IC50 51 μM) and hydrogen
peroxide (IC50 141 μM) radicals as well as a reducing power assay.
The results suggest that butyrolactone I is a promising antidiabetic as
well as antioxidant and should be considered for clinical trials.
Open Science Index 70, 2012