@article{(Open Science Index):https://publications.waset.org/pdf/5182,
	  title     = {Antidiabetic and Antioxidative Activities of Butyrolactone I from Aspergillus terreus MC751},
	  author    = {Rizna Triana Dewi and  Sanro Tachibana and  Ahmad Darmawan},
	  country	= {},
	  institution	= {},
	  abstract     = {The bioassay-guided isolation and purification of an
ethyl acetate extract of Aspergillus terreus MC751 led to the
characterization of butyrolactone I as an antidiabetic and antioxidant.
The antidiabetic activity of butyrolactone I was evaluated by α-
glucosidase and α-amylase inhibition assays. Butyrolactone I
demonstrated significant concentration-dependent, mixed-type
inhibitory activity against yeast α-glucosidase with an IC50 of 54μM.
However, the compound exhibited less activity against rat intestinal
α-glucosidase and α-amylase. This is the first report on α-glucosidase
inhibitory activity of butyrolactone I. The antioxidative activity of
butyrolactone I was evaluated based on scavenging effects on 1,1-
diphenyl-2-picrylhydrazyl (DPPH) (IC50 =51 μM) and hydrogen
peroxide (IC50= 141 μM) radicals as well as a reducing power assay.
The results suggest that butyrolactone I is a promising antidiabetic as
well as antioxidant and should be considered for clinical trials.},
	    journal   = {International Journal of Biotechnology and Bioengineering},
	  volume    = {6},
	  number    = {10},
	  year      = {2012},
	  pages     = {929 - 934},
	  ee        = {https://publications.waset.org/pdf/5182},
	  url   	= {https://publications.waset.org/vol/70},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 70, 2012},
	}