@article{(Open Science Index):https://publications.waset.org/pdf/3621,
	  title     = {Endothelial Specificity of ICAM2, Flt-1, and Tie2 Promoters In Vitro and In Vivo},
	  author    = {Jing Lei and  Yoram Vodovotz and  Timothy R. Billiar},
	  country	= {},
	  institution	= {},
	  abstract     = {To identify an endothelial cell-specific promoter suitable for vascular-specific targeting, we tested five promoters in vitro--Tie2SE, Tie2LE, ICAM2, Flt-1 and vWF--for promoter activity and specificity in endothelial cells, smooth muscle cells and non-vascular resident cells as well as tissues. These promoters, except for vWF, exhibited good endothelial activity and specificity in vitro. In a syngenic heart transplantation model, the ICAM2 promoter was variably functional in coronary endothelial cells of donor hearts. Thus, the ICAM2, Flt-1, Tie2SE and Tie2LE promoters hold promise for endothelial-specific targeting, but in vitro expression may not predict in vivo expression.
},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {1},
	  number    = {5},
	  year      = {2007},
	  pages     = {250 - 254},
	  ee        = {https://publications.waset.org/pdf/3621},
	  url   	= {https://publications.waset.org/vol/5},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 5, 2007},
	}