@article{(Open Science Index):https://publications.waset.org/pdf/1938,
	  title     = {Herpes Simplex Virus Type I Infection of Mice Testis and Effect on Fertility},
	  author    = {Victor A. Naumenko and  Yuriy A. Tyulenev and  Alla A. Kushch},
	  country	= {},
	  institution	= {},
	  abstract     = {The objective of current issue was to develop a model
of testicular herpes simplex virus (HSV) type I infection for
assessment of viral effect on fertility. 56 male mice were inoculated
intraperitoneally with different concentrations of HSV on 8 day post
partum. It was revealed that the optimal dose was 100 plaque
forming units per mice as it provided testicular infection in 100% of
survivors. HSV proteins were detected both in somatic and germ
cells (spermatogonia, spermatocytes, spermatides). Although DNA
load in testis was descending from 3 to 28 days post infection only
12.5% of infected males had offspring after mating with uninfected
females comparing to 87.5% in control (p=0.012). These results are
the first direct evidence for HSV impact in male sterility. Prepuberal
mice appeared to be a suitable model for investigation of
pathogenesis of virus-associated fertility disorders.},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {6},
	  number    = {12},
	  year      = {2012},
	  pages     = {703 - 706},
	  ee        = {https://publications.waset.org/pdf/1938},
	  url   	= {https://publications.waset.org/vol/72},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 72, 2012},
	}