@article{(Open Science Index):https://publications.waset.org/pdf/17155, title = {Effect of pH and Ionic Exchange on the Reactivity of Bioglass/Chitosan Composites Used as a Bone Graft Substitute}, author = {Samira Jebahi and Hassane Oudadesse and Eric Wers and Jiheun Elleuch and Hafedh Elfekih and Hassib Keskes and Xuan Vuong Bui and Abdelfatteh Elfeki}, country = {}, institution = {}, abstract = {Chitosan (CH) material reinforced by bioactive glass (46S6) was fabricated. 46S6 containing 17% wt% CH was studied in vitro and in vivo. Physicochemical techniques, such as Fourier transform infrared spectroscopy (FT-IR), coupled plasma optical emission spectrometry (ICP-OES) analysis were used. The behavior of 46S6CH17 was studied by measuring the in situ pH in a SBF solution. The 46S6CH17 was implanted in the rat femoral condyl. In vitro 46S6CH17 gave an FTIR - spectrum in which three absorption bands with the maxima at 565, 603 and 1039cm-1 after 3 days of soaking in physiological solution. They are assigned to stretching vibrations of PO4^3- group in phosphate crystalline. Moreover, the pH measurement was decreased in the SBF solution. The stability of the calcium phosphate precipitation depended on the pH value. In vivo, a rise in the Ca and phosphate P ions concentrations in the implanted microenvironment was determined. }, journal = {International Journal of Materials and Metallurgical Engineering}, volume = {7}, number = {5}, year = {2013}, pages = {304 - 309}, ee = {https://publications.waset.org/pdf/17155}, url = {https://publications.waset.org/vol/77}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 77, 2013}, }