@article{(Open Science Index):https://publications.waset.org/pdf/16459, title = {Dextran/Poly(L-histidine) Graft Copolymer for pH-Responsive Drug Delivery}, author = {Dae Hwan Kang and Young-IL Jeong and Chung-Wook Chung}, country = {}, institution = {}, abstract = {pH-sensitive drug targeting using nanoparticles for cancer chemotherapy have been spotlighted in recent decades. Graft copolymer composed of poly (L-histidine) (PHS) and dextran (DexPHS) was synthesized and pH-sensitive nanoparticles were fabricated for pH-responsive drug delivery of doxorubicin (DOX). Nanoparticles of DexPHS showed pH-sensitive changes in particle sizes and drug release behavior, i.e. particle sizes and drug release rate were increased at acidic pH, indicating that DexPHS nanoparticles have pH-sensitive drug delivery potentials. Antitumor activity of DOX-incorporated DexPHS nanoparticles were studied using CT26 colorectal carcinoma cells. Results indicated that fluorescence intensity was higher at acidic pH than basic pH. These results indicated that DexPHS nanoparticles have pH-responsive drug targeting. }, journal = {International Journal of Pharmacological and Pharmaceutical Sciences}, volume = {7}, number = {7}, year = {2013}, pages = {402 - 405}, ee = {https://publications.waset.org/pdf/16459}, url = {https://publications.waset.org/vol/79}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 79, 2013}, }