Pre-Clinical Studying of Antitumor Ramon Preparation: Acute Toxicity

Authors: Raissa A. Muzychkina, Irina M. Korulkina, Dmitriy Yu. Korulkin

Abstract:

In article the data of acute toxicity for pre-clinical researches of Ramon preparation is described. Ramon effects to clinical characteristics of blood, cardio-vascular system, hepatotoxic and diuretic effects were studied.

Keywords: Cancer, toxicity, antitumor activity, pre-clinical testing, anthraquinones, phytopreparation, Ramon.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1086819

References:

[1] M.Hidalgo, E.Garrett-Mayer, N.J.Clendeninn, S.G.Ekhardt, Principles of Anticancer Drug Development, New York: Springer, 2011.
[2] J.Y.Chang, A.J.LewisPharmacological Methods in the Control of Inflammation, Wiley-Blackwell, New-York, 1989.
[3] S.K.Gupta, Drug Screening Methods, Kent: Anshan Publishers, 2009.
[4] A.A.Adjei, J.K.Buolamwini, Novel Anticancer Drug Protocols, New York: Academic Press, 2011
[5] H.G.Vogel, J.Maas, A.Gebauer, Drug Discovery and Evaluation: Methods in Clinical Pharmacology, Berlin: Springer, 2011.
[6] A.A.AlFattah Amara, “Methods other than Experimental Animals for Screening Antitumor Compounds,” Am. J. Cancer Sci., vol. 2, no. 1, pp. 1-27, 2013.
[7] J.Kolman, P.Meng, G.Scott,Good clinical practice: standard operating procedures for clinical researchers, New-York:J. Wiley & Sons, 1998.