@article{(Open Science Index):https://publications.waset.org/pdf/16143,
	  title     = {Is Curcumine Effect Comparable to 5- Aminosalicylic Acid or Budesonide on a Rat Model of Ulcerative Colitis Induced by Trinitrobenzene Sulfonic Acid?},
	  author    = {Inas E. Darwish and  Alia M. Arab and  Tarek A. Azeim and  Teshreen M. Zeitoun and  Wafaa A. Hewedy and  Moemen A. Heiba and  Iman S. Emara},
	  country	= {},
	  institution	= {},
	  abstract     = {Inflammatory bowel disease (IBD) is a chronic
relapsing-remitting condition that afflicts millions of people
throughout the world and impairs their daily functions and quality of
life. Treatment of IBD depends largely on 5-aminosalicylic acid (5-
ASA) and corticosteroids. The present study aimed to clarify the
effects of 5-aminosalicylic acid, budesonide and currcumin on 90
male albino rats against trinitrobenzene sulfonic acid (TNB) induced
colitis. TNB was injected intrarectally to 50 rats. The other 40 rats
served as control groups. Both 5-ASA (in a dose of 120 mg/kg) and
budesonide (in a dose of 0.1 mg/kg) were administered daily for one
week whereas currcumin was injected intraperitonially (in a dose of
30 mg/kg daily) for 14 days after injection of either TNB in the
colitis rats (group B) or saline in control groups (group A). The study
included estimation of macroscopic score index, histological
examination of H&E stained sections of the colonic tissue,
biochemical estimation of myeloperoxidase (MPO), nitric oxide
(NO), and caspase-3 levels, in addition to studying the effect of tested
drugs on colonic motility. It was found that budesonide and curcumin
improved mucosal healing, reduced both NO production and caspase-
3 level. They had the best impact on the disturbed colonic motility in
TNBS-model of colitis.
},
	    journal   = {International Journal of Medical and Health Sciences},
	  volume    = {7},
	  number    = {8},
	  year      = {2013},
	  pages     = {447 - 455},
	  ee        = {https://publications.waset.org/pdf/16143},
	  url   	= {https://publications.waset.org/vol/80},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 80, 2013},
	}