%0 Journal Article
	%A S. Fallah and  M. Seifi and  M. Firoozrai and  T. Godarzi and  M. Jafarzadeh and  L. H. Ghohari
	%D 2009
	%J International Journal of Medical and Health Sciences
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 33, 2009
	%T Influence of Apo E Polymorphism on Coronary Artery Disease
	%U https://publications.waset.org/pdf/15087
	%V 33
	%X The ε4 allele of the ε2, ε3 and ε4 protein isoform polymorphism in the gene encoding apolipoprotein E (Apo E) has previously been associated with increased cardiac artery disease (CAD); therefore to investigate the significance of this polymorphism in pathogenesis of CAD in Iranian patients with stenosis and control subjects. To investigate the association between 
Apo E polymorphism and coronary artery disease we performed a comparative case control study of the frequency of Apo E 
polymorphism in One hundred CAD patients with stenosis who underwent coronary angiography (>50% stenosis) and 100 control subjects (<10% stenosis). The Apo E alleles and genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). We observed an association between the Apo E polymorphism and CAD in this study. These data suggest that the Apo ε4 and ε2 alleles increase the risk for CAD in Iranian population (χ2 =4.26, p= 0.05, OR=2 and χ2 =0.38, p=0.53, OR=1.2). These results suggest that ε4 and ε2 alleles are risk factors for stenosis.

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