@article{(Open Science Index):https://publications.waset.org/pdf/15087, title = {Influence of Apo E Polymorphism on Coronary Artery Disease}, author = {S. Fallah and M. Seifi and M. Firoozrai and T. Godarzi and M. Jafarzadeh and L. H. Ghohari}, country = {}, institution = {}, abstract = {The ε4 allele of the ε2, ε3 and ε4 protein isoform polymorphism in the gene encoding apolipoprotein E (Apo E) has previously been associated with increased cardiac artery disease (CAD); therefore to investigate the significance of this polymorphism in pathogenesis of CAD in Iranian patients with stenosis and control subjects. To investigate the association between Apo E polymorphism and coronary artery disease we performed a comparative case control study of the frequency of Apo E polymorphism in One hundred CAD patients with stenosis who underwent coronary angiography (>50% stenosis) and 100 control subjects (<10% stenosis). The Apo E alleles and genotypes were determined by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP). We observed an association between the Apo E polymorphism and CAD in this study. These data suggest that the Apo ε4 and ε2 alleles increase the risk for CAD in Iranian population (χ2 =4.26, p= 0.05, OR=2 and χ2 =0.38, p=0.53, OR=1.2). These results suggest that ε4 and ε2 alleles are risk factors for stenosis. }, journal = {International Journal of Medical and Health Sciences}, volume = {3}, number = {9}, year = {2009}, pages = {246 - 250}, ee = {https://publications.waset.org/pdf/15087}, url = {https://publications.waset.org/vol/33}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 33, 2009}, }