%0 Journal Article
	%A Tze Sian Pui and  Tushar Bansal and  Patthara Kongsuphol and  Sunil K. Arya
	%D 2012
	%J International Journal of Biomedical and Biological Engineering
	%B World Academy of Science, Engineering and Technology
	%I Open Science Index 69, 2012
	%T Highly Sensitive Label Free Biosensor for Tumor Necrosis Factor
	%U https://publications.waset.org/pdf/1316
	%V 69
	%X We present a label-free biosensor based on
electrochemical impedance spectroscopy for the detection of proinflammatory
cytokine Tumor Necrosis Factor (TNF-α). Secretion of
TNF-α has been correlated to the onset of various diseases including
rheumatoid arthritis, Crohn-s disease etc. Gold electrodes were
patterned on a silicon substrate and self assembled monolayer of
dithiobis-succinimidyl propionate was used to develop the biosensor
which achieved a detection limit of ~57fM. A linear relationship was
also observed between increasing TNF-α concentrations and chargetransfer
resistance within a dynamic range of 1pg/ml – 1ng/ml.
	%P 443 - 446