Jin Sun Oh and Kyung Ho Lee and S ang Gug Chung and Kyehan Rhee
A Preliminary Study of Drug Perfusion Enhancement by Microstreaming Induced by an Oscillating Microbubble
551 - 553
2012
6
11
International Journal of Pharmacological and Pharmaceutical Sciences
https://publications.waset.org/pdf/1313
https://publications.waset.org/vol/71
World Academy of Science, Engineering and Technology
Microbubbbles incorporating ultrasound have been used to increase the efficacy of targeted drug delivery, because microstreaming induced by cavitating bubbles affects the drug perfusion into the target cells and tissues. In order to clarify the physical effects of microstreaming on drug perfusion into tissues, a preliminary experimental study of perfusion enhancement by a stably oscillating microbubble was performed. Microstreaming was induced by an oscillating bubble at 15 kHz, and perfusion of dye into an agar phantom was optically measured by histology on agar phantom. Surface color intensity and the penetration length of dye in the agar phantom were increased more than 70 and 30, respectively, due to the microstreaming induced by an oscillating bubble. The mass of dye perfused into a tissue phantom for 30 s was increased about 80 in the phantom with an oscillating bubble. This preliminary experiment shows the physical effects of steady streaming by an oscillating bubble can enhance the drug perfusion into the tissues while minimizing the biological effects.
Open Science Index 71, 2012