Modeling of Bio Scaffolds: Structural and Fluid Transport Characterization
Scaffolds play a key role in tissue engineering and can be produced in many different ways depending on the applications and the materials used. Most researchers used an experimental trialand- error approach into new biomaterials but computer simulation applied to tissue engineering can offer a more exhaustive approach to test and screen out biomaterials. This paper develops the model of scaffolds and Computational Fluid Dynamics that show the value of computer simulations in determining the influence of the geometrical scaffold parameter porosity, pore size and shape on the permeability of scaffolds, magnitude of velocity, drop pressure, shear stress distribution and level and the proper design of the geometry of the scaffold. This creates a need for more advanced studies that include aspects of dynamic conditions of a micro fluid passing through the scaffold were characterized for tissue engineering applications and differentiation of tissues within scaffolds.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1078042Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1424
 A. G. Mikos and J. S. Temenoff, Formation of highly porous biodegradable scaffolds for tissue engineering, EJB Electronic Journal of Biotechnology 3(2): 1-6, 2000.
 Freed, L.E., Vunjac-Novakovic, G., "Tissue engineering of cartilage", In: Bronzino, J.D. (Ed.), The Biomedical Engineering Handbook. CRC Press, Boca Raton, FL, pp. 1788-1806, 1995
 Freed, L.E., Langer, R., Martin, I., Pellis, N.R., Vunjak-Novakovic, G., "Tissue engineering of cartilage in space", Proceedings of the National Academy of Sciences USA 94 (25), pp. 1385-1390, 1997
 Kellner, K., Liebsch, G., Klimant, I., Wolfbeis, O.S., Blunk, T., Schulz, M.B., Gopferich, A., "Determination of oxygen gradients in engineered tissue using a fluorescent sensor", Biotechnology and Bioengineering 80 (1), pp. 73-83, 2002
 Sun, W. & Lal, P., Recent development on computer aided tissue engineeringÔÇöa review, Comput. Methods Prog. Biomed. 67, 85-103. 2002
 Sun, W., Darling, A., Starly, B. & Nam, J., Computer aided tissue engineering: overview, scope and challenges, J. Biotechnol. Appl. Biomech. 39, 29-47, 2004.
 Cioffi, M., Boschetti, F., Raimondi, M. T. & Dubini, G., Modeling evaluation of the fluid dynamic microenvironment in tissue-engineered constructs: a micro-CT based model, Biotechnol. Bioeng. 93, 500-510, 2006.
 Boschetti F, Raimondi MT, Migliavacca F, Dubini G, "Prediction of the micro-fluid dynamic environment imposed to three-dimensional engineered cell systems in bioreactors", Journal Biomechanics 39(3), pp. 418-425. 2006.
 Sandino, C., Planell, J. A. & Lacroix, D., A finite element study of mechanical stimuli in scaffolds for bone tissue engineering, J. Biomech. 41, 1005-1014, 2008
 Scheidegger A E, "The Physics of Flow through Porous Media" (Toronto, Canada: University of Toronto Press), 1974.