{"title":"Modeling of Bio Scaffolds: Structural and Fluid Transport Characterization","authors":"Sahba Sadir, M. R. A. Kadir, A. \u00d6chsner, M. N. Harun","volume":50,"journal":"International Journal of Mechanical and Mechatronics Engineering","pagesStart":397,"pagesEnd":403,"ISSN":"1307-6892","URL":"https:\/\/publications.waset.org\/pdf\/11844","abstract":"
Scaffolds play a key role in tissue engineering and can be produced in many different ways depending on the applications and the materials used. Most researchers used an experimental trialand- error approach into new biomaterials but computer simulation applied to tissue engineering can offer a more exhaustive approach to test and screen out biomaterials. This paper develops the model of scaffolds and Computational Fluid Dynamics that show the value of computer simulations in determining the influence of the geometrical scaffold parameter porosity, pore size and shape on the permeability of scaffolds, magnitude of velocity, drop pressure, shear stress distribution and level and the proper design of the geometry of the scaffold. This creates a need for more advanced studies that include aspects of dynamic conditions of a micro fluid passing through the scaffold were characterized for tissue engineering applications and differentiation of tissues within scaffolds.<\/p>\r\n","references":"[1] A. G. Mikos and J. S. Temenoff, Formation of highly porous\r\nbiodegradable scaffolds for tissue engineering, EJB Electronic Journal of\r\nBiotechnology 3(2): 1-6, 2000.\r\n[2] Freed, L.E., Vunjac-Novakovic, G., \"Tissue engineering of cartilage\",\r\nIn: Bronzino, J.D. (Ed.), The Biomedical Engineering Handbook. CRC\r\nPress, Boca Raton, FL, pp. 1788-1806, 1995\r\n[3] Freed, L.E., Langer, R., Martin, I., Pellis, N.R., Vunjak-Novakovic, G.,\r\n\"Tissue engineering of cartilage in space\", Proceedings of the National\r\nAcademy of Sciences USA 94 (25), pp. 1385-1390, 1997\r\n[4] Kellner, K., Liebsch, G., Klimant, I., Wolfbeis, O.S., Blunk, T., Schulz,\r\nM.B., Gopferich, A., \"Determination of oxygen gradients in engineered\r\ntissue using a fluorescent sensor\", Biotechnology and Bioengineering 80\r\n(1), pp. 73-83, 2002\r\n[5] Sun, W. & Lal, P., Recent development on computer aided tissue\r\nengineering\u00d4\u00c7\u00f6a review, Comput. Methods Prog. Biomed. 67, 85-103.\r\n2002\r\n[6] Sun, W., Darling, A., Starly, B. & Nam, J., Computer aided tissue\r\nengineering: overview, scope and challenges, J. Biotechnol. Appl.\r\nBiomech. 39, 29-47, 2004.\r\n[7] Cioffi, M., Boschetti, F., Raimondi, M. T. & Dubini, G., Modeling\r\nevaluation of the fluid dynamic microenvironment in tissue-engineered\r\nconstructs: a micro-CT based model, Biotechnol. Bioeng. 93, 500-510,\r\n2006.\r\n[8] Boschetti F, Raimondi MT, Migliavacca F, Dubini G, \"Prediction of the\r\nmicro-fluid dynamic environment imposed to three-dimensional\r\nengineered cell systems in bioreactors\", Journal Biomechanics 39(3), pp.\r\n418-425. 2006.\r\n[9] Sandino, C., Planell, J. A. & Lacroix, D., A finite element study of\r\nmechanical stimuli in scaffolds for bone tissue engineering, J. Biomech.\r\n41, 1005-1014, 2008\r\n[10] Scheidegger A E, \"The Physics of Flow through Porous Media\"\r\n(Toronto, Canada: University of Toronto Press), 1974.","publisher":"World Academy of Science, Engineering and Technology","index":"Open Science Index 50, 2011"}