%0 Journal Article %A Qiu Chen and Feifei Lee and Koji Kotani and Tadahiro Ohmi %D 2010 %J International Journal of Biomedical and Biological Engineering %B World Academy of Science, Engineering and Technology %I Open Science Index 45, 2010 %T An Improved Fast Search Method Using Histogram Features for DNA Sequence Database %U https://publications.waset.org/pdf/10985 %V 45 %X In this paper, we propose an efficient hierarchical DNA sequence search method to improve the search speed while the accuracy is being kept constant. For a given query DNA sequence, firstly, a fast local search method using histogram features is used as a filtering mechanism before scanning the sequences in the database. An overlapping processing is newly added to improve the robustness of the algorithm. A large number of DNA sequences with low similarity will be excluded for latter searching. The Smith-Waterman algorithm is then applied to each remainder sequences. Experimental results using GenBank sequence data show the proposed method combining histogram information and Smith-Waterman algorithm is more efficient for DNA sequence search. %P 696 - 699