WASET
	@article{(Open Science Index):https://publications.waset.org/pdf/10654,
	  title     = {Effect of L-Arginine on Neuromuscular Transmission of the Chick Biventer Cervicis Muscle},
	  author    = {S. Asadzadeh Vostakolaei},
	  country	= {},
	  institution	= {},
	  abstract     = {In this study, the effect of L-arginine was examined at the neuromuscular junction of the chick biventer cervicis muscle. LArginine at 500 μg/ ml, decreased twitch response to electerical stimulation, and produced rightward shift of the dose- response curve for acetylcholine or carbachol. L-Arginine at 1000μg/ ml produced a strong shift to the right of the dose – response curve for acetylcholine or carbachol with a reduction in the efficacy. The inhibitory effect of L-arginine on the twitch response was blocked by caffeine (200μg/ ml). NO levels were also measured in the chick biventer cervicis muscle homogenates, using spectrophotometric method for the direct detection of NO, nitrite and nitrate. Total nitrite (nitrite + nitrate) was measured by a spectrophotometer at 540 nm after the conversion of nitrate to nitrite by copperized cadmium granules. NO levels were found to be significantly increased in concentrations 500 and 1000μg/ ml of L-arginine in comparison with the control group (p<0.001). These findings indicate a possible role of increased NO levels in the suppressive action of L-arginine on the twitch response. In addition, the results indicate that the post- junctional antagonistic action of L-arginine is probably the result of impaired sarcoplasmic reticulum (SR) Ca+2 releases.
},
	    journal   = {International Journal of Animal and Veterinary Sciences},
	  volume    = {3},
	  number    = {9},
	  year      = {2009},
	  pages     = {446 - 449},
	  ee        = {https://publications.waset.org/pdf/10654},
	  url   	= {https://publications.waset.org/vol/33},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 33, 2009},
	}