TY - JFULL AU - Weronika Kurowska-Nouyrigat and Jacek Szumbarski PY - 2009/11/ TI - Numerical Simulation of Restenosis in a Stented Coronary Artery T2 - International Journal of Medical and Health Sciences SP - 267 EP - 272 VL - 3 SN - 1307-6892 UR - https://publications.waset.org/pdf/10419 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 34, 2009 N2 - Nowadays, cardiac disease is one of the most common cause of death. Each year almost one million of angioplasty interventions and stents implantations are made all over the world. Unfortunately, in 20-30% of cases neointimal proliferations leads to restenosis occurring within the following period of 3-6 months. Three major factors are believed to contribute mostly to the edge restenosis: (a) mechanical damage of the artery-s wall caused by the stent implantation, (b) interaction between the stent and the blood constituents and (c) endothelial growth stimulation by small (lower that 1.5 Pa) and oscillating wall shear stress. Assuming that this last actor is particularly important, a numerical model of restenosis basing on wall shear stress distribution in the stented artery was elaborated. A numerical simulations of the development of in-stent restenosis have been performed and realistic geometric patterns of a progressing lumen reduction have been obtained ER -