@article{(Open Science Index):https://publications.waset.org/pdf/10403,
	  title     = {Combining Similarity and Dissimilarity Measurements for the Development of QSAR Models Applied to the Prediction of Antiobesity Activity of Drugs },
	  author    = {Irene Luque Ruiz and  Manuel Urbano Cuadrado and  Miguel Ángel Gómez-Nieto},
	  country	= {},
	  institution	= {},
	  abstract     = {In this paper we study different similarity based approaches for the development of QSAR model devoted to the prediction of activity of antiobesity drugs. Classical similarity approaches are compared regarding to dissimilarity models based on the consideration of the calculation of Euclidean distances between the nonisomorphic fragments extracted in the matching process. Combining the classical similarity and dissimilarity approaches into a new similarity measure, the Approximate Similarity was also studied, and better results were obtained. The application of the proposed method to the development of quantitative structure-activity relationships (QSAR) has provided reliable tools for predicting of inhibitory activity of drugs. Acceptable results were obtained for the models presented here. },
	    journal   = {International Journal of Pharmacological and Pharmaceutical Sciences},
	  volume    = {1},
	  number    = {4},
	  year      = {2007},
	  pages     = {217 - 222},
	  ee        = {https://publications.waset.org/pdf/10403},
	  url   	= {https://publications.waset.org/vol/4},
	  bibsource = {https://publications.waset.org/},
	  issn  	= {eISSN: 1307-6892},
	  publisher = {World Academy of Science, Engineering and Technology},
	  index 	= {Open Science Index 4, 2007},
	}