Mustafa M. Donma and Orkide Donma
The Evaluation of Complete Blood Cell CountBased Inflammatory Markers in Pediatric Obesity and Metabolic Syndrome
89 - 92
2020
14
3
International Journal of Medical and Health Sciences
https://publications.waset.org/pdf/10011092
https://publications.waset.org/vol/159
World Academy of Science, Engineering and Technology
Obesity is defined as a severe chronic disease characterized by a lowgrade inflammatory state. Therefore, inflammatory markers gained utmost importance during the evaluation of obesity and metabolic syndrome (MetS), a disease characterized by central obesity, elevated blood pressure, increased fasting blood glucose and elevated triglycerides or reduced high density lipoprotein cholesterol (HDLC) values. Some inflammatory markers based upon complete blood cell count (CBC) are available. In this study, it was questioned which inflammatory marker was the best to evaluate the differences between various obesity groups. 514 pediatric individuals were recruited. 132 children with MetS, 155 morbid obese (MO), 90 obese (OB), 38 overweight (OW) and 99 children with normal BMI (NBMI) were included into the scope of this study. Obesity groups were constituted using age and sexdependent body mass index (BMI) percentiles tabulated by World Health Organization. MetS components were determined to be able to specify children with MetS. CBC were determined using automated hematology analyzer. HDLC analysis was performed. Using CBC parameters and HDLC values, ratio markers of inflammation, which cover neutrophiltolymphocyte ratio (NLR), derived neutrophiltolymphocyte ratio (dNLR), platelettolymphocyte ratio (PLR), lymphocytetomonocyte ratio (LMR), monocytetoHDLC ratio (MHR) were calculated. Statistical analyses were performed. The statistical significance degree was considered as p < 0.05. There was no statistically significant difference among the groups in terms of platelet count, neutrophil count, lymphocyte count, monocyte count, and NLR. PLR differed significantly between OW and NBMI as well as MetS. Monocyteto HDLC value exhibited statistical significance between MetS and NBMI, OB, and MO groups. HDLC value differed between MetS and NBMI, OW, OB, MO groups. MHR was the ratio, which exhibits the best performance among the other CBCbased inflammatory markers. On the other hand, when MHR was compared to HDLC only, it was suggested that HDLC has given much more valuable information. Therefore, this parameter still keeps its value from the diagnostic point of view. Our results suggest that MHR can be an inflammatory marker during the evaluation of pediatric MetS, but the predictive value of this parameter was not superior to HDLC during the evaluation of obesity.
Open Science Index 159, 2020