Hafiz Muhammad Obaid and Bilal Wajid and Nauman Haider and Muhammad Zafrullah
Comparison of Diagnostic Performance of Soluble Transferrin Receptor and Soluble Transferrin ReceptorFerritin Index Tests in the Diagnosis of Iron Deficiency Anemia
690 - 695
2017
11
12
International Journal of Medical and Health Sciences
https://publications.waset.org/pdf/10008659
https://publications.waset.org/vol/132
World Academy of Science, Engineering and Technology
In this research article, a comprehensive analysis is performed to compare the diagnostic performance of soluble transferrin receptor (sTfR) and sTfRlog ferritin index tests in the differential diagnosis of iron deficiency anemia (IDA) and anemia of chronic disease (ACD). The analysis is performed for both sTfR and sTfRlog ferritin index using a set of 11 studies. The overall odds ratios for sTfR and sTfRlog ferritin index were 36.79 and 119.32 respectively, using 95 confidence interval. The relative sensitivity, specificity. positive likelihood ratio (LR) and negative LR values for sTfR in relation to sTfRlog ferritin index were 81 vs 85, 84 vs 93, 6.31 vs 13.95 and 0.18 vs 0.14 respectively. The summary receiver operating characteristic (SROC) curves are also plotted for both sTfR and sTfRlog ferritin index. The area under SROC curves for sTfR and sTfRlog ferritin index was found to be 0.9296 and 0.9825 respectively. Although both tests are useful, the sTfRlog ferritin index seems to be more effective when compared with sTfR.
Open Science Index 132, 2017