Alteration of Bone Strength in Osteoporosis of Mouse Femora: Computational Study Based on Micro CT Images
The purpose of the study is to develop a finite element model based on 3D bone structural images of Micro-CT and to analyze the stress distribution for the osteoporosis mouse femora. In this study, results of finite element analysis show that the early osteoporosis of mouse model decreased a bone density in trabecular region; however, the bone density in cortical region increased.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1339199Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1122
 B. V. Rietbergen, et al., “A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models,” J Biomech, 28, 1995, pp. 69-81.
 M. Joshua, B. Steven, “Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method,” Bone 42, 2008, pp. 1203-1213.
 J. Y. Rho, et al., “Relations of mechanical properties to density and CT numbers in human bone,” Med Eng Phys, 17, 1995, pp. 347-355.
 T. L. Mueller, et al., “Non-invasive bone competence analysis by high-resolution pQCT: an in vitro reproducibility study on structural and mechanical properties at the human radius,” Bone, 44(2), 2009, pp. 364-371.
 X. S. Liu, et al., “High resolution peripheral quantitative computed tomography can assess microstructural and mechanical properties of human distal tibial bone,” J Bone Miner Res, 25(4), 2010, pp. 746-756.
 H. M. Macdonald, et al., “Age-related patterns of trabecular and cortical bone loss differ between sexes and skeletal sites: A population-based HR-pQCT study,” J Bone Miner Res, 26(1), 2011, pp. 50-62.
 H. M. Macdonald, et al., “Changes in trabecular and cortical bone microarchitecture at peripheral sites associated with 18 months of teriparatide therapy in postmenopausal women with osteorosis,” Osteoporosis international, 22, 2010, pp. 357-362.
 R. Rizzoli, et al., “Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis,” Osteoporosis international, 23, 2012, pp. 305-315.
 S. A. Jamal, et al., “Effect of nitroglycerin ointment on bone density and strength in postmenopausal women,” J Am Med Assoc., 305(8), 2011, pp. 800-807.
 S. Hansen, et al., “Differing effects of PTH 1-34, PTH 1-84, and zoledronic acid on bone microarchitecture and estimated strength in postmenopausal women with osteoporosis: An 18-month open-labeled observational study using HR-pQCT,” J Bone Miner Res, 28(4), 2013, pp. 736-745.