TY - JFULL AU - M. M. Bashandy and A. R. Ahmed and M. El-Gaffary and Sahar S. Abd El-Rahman PY - 2015/12/ TI - Gold Nanoparticle: Synthesis, Characterization, Clinico-Pathological, Pathological, and Bio-Distribution Studies in Rabbits T2 - International Journal of Pharmacological and Pharmaceutical Sciences SP - 1167 EP - 1174 VL - 9 SN - 1307-6892 UR - https://publications.waset.org/pdf/10003113 PU - World Academy of Science, Engineering and Technology NX - Open Science Index 107, 2015 N2 - This study evaluated the acute toxicity and tissue distribution of intravenously administered gold nanoparticles (AuNPs) in male rabbits. Rabbits were exposed to single dose of AuNPs (300 μg/ kg). Toxic effects were assessed via general behavior, hematological parameters, serum biochemical parameters, and histopathological examination of various rabbits’ organs. Inductively coupled plasma–mass spectrometry (ICP-MS) was used to determine gold concentrations in tissue samples collected at predetermined time intervals. After one week, AuNPs exerted no obvious acute toxicity in rabbits. However, inflammatory reactions were observed in liver, lungs and kidneys accompanied with mild absolute neutrophilia and significant monocytosis. The highest gold levels were found in the spleen and liver followed by lungs, and kidneys. These results indicated that AuNPs could be distributed extensively to various tissues in the body, but primarily in the spleen and liver. ER -