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Association of Overweight and Obesity with Breast Cancer
Abstract:Breast cancer is in the top rate of cancer. We analyzed the prevalence of obesity and its association with breast cancer and finally we reviewed 25 article that 320 patient and 320 control which enrolled to our study. The distribution of breast cancer patients and controls with respect to their anthropometric indices in patients with higher weight, which was statistically significant (60.2 ± 10.2 kg) compared with control group (56.1 ± 11.3 kg). The body mass index of patients was (26.06+/-3.42) and significantly higher than the control group (24.1+/-1.7). Obesity leads to increased levels of adipose tissue in the body that can be stored toxins and carcinogens to produce a continuous supply. Due to the high level of fat and the role of estrogen in a woman which is endogenous estrogen of the tumor and regulates the activities of growth steroids, obesity has confirmed as a risk factor for breast cancer. Our study and other studies have shown that obesity is a risk factor for breast cancer. And it can be prevented with a weight loss intervention for breast cancer in the future.
Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1107710Procedia APA BibTeX Chicago EndNote Harvard JSON MLA RIS XML ISO 690 PDF Downloads 1352
 American Cancer Society. Breast Cancer: Facts and Figures 2011–2012. Available online: http://www.cancer.org/research/cancerfactsfigures/ breastcancerfactsfigures/breast-cancer-facts-and-figures-2011–2012 (accessed on 21 May 2014).
 Howlader, N.; Noone, A. M.; Krapcho, M.; Garshell, J.; Miller, D.; Altekruse, S. F.; Kosary, C. L.; Yu, M.; Ruhl, J.; Tatalovich, Z.; et al. SEER Cancer Statistics Review, 1975–2011. Available online: http://seer.cancer.gov/csr/1975_2011 (accessed on 21 May 2014).
 National Cancer Institute. Cancer Trends Progress Report—2011–2012 Update. Available online: http://progressreport.cancer.gov (accessed on 21 May 2014).
 Lin TM, Chen KP, MacMohan B. Epidemiological characteristics of cancer of the breast in Taiwan. Cancer. 1971; 27:1497–504. (PubMed).
 Li CI, Malone KE, White E, et al. Age when maximum height is reached as a risk factor for breast cancer among young U.S. Epidemiology. 1997; 8:559–65. (PubMed).
 Matusitz, McCornick (2012). Sendentarism: the effect of Internet use on human obesity in the United States. Soc Work Public Health, 27, 250-69.
 Calle EE, Kaaks R (2004). Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nature Reviews Cancer, 4, 579-91.
 De Pergola G, Silvestris F (2013). Obesity as a major risk factor for cancer. J Obes, 2013, 291546.
 Wang YC, McPherson K, Marsh T, Gortmaker SL, Brown M (2011). Health and economic burden of the projected obesity.
 Bergström A, Pisani P, Tenet V, Wolk A, Adami H-O (2001). Overweight as an avoidable cause of cancer in Europe. Int J Cancer 2001 Jun 15; 92(6):927.
 Weir R, Day P, Ali W (2007). Risk factors for breast cancer in women. New Zealand Health Technology Assessment. NZHTA Report, 10, 1- 361.
 Renehan AG, Tyson M, Egger M, Heller RF, Zwahlen M (2008). Bodymass index and incidence of cancer: a systematic review and metaanalysis of prospective observational studies. Lancet, 371, 569-78.
 Friedenreich CM. Physical activity and cancer: lessons learned from nutritional epidemiology. Nutr Rev. 2001; 59:349–57. (PubMed)
 Graham S, Hellmann R, Marshall J, et al. Nutritional epidemiology of postmenopausal breast cancer in western New York. Am J Epidemiol. 1991; 134:552–66. (PubMed).
 Stoll BA. Diet and exercise regimens to improve breast carcinoma prognosis. Cancer. 1996; 78:2465–70. (PubMed).
 Key TJ, Pike MC. The role of estrogens and progestragens in the epidemiology and prevention of breast cancer. Eur J Cancer Clin Oncol. 1988; 24:29–43. (PubMed).
 Schapira DV, Kumar NB, Lyman GH, et al. Abdominal obesity and breast cancer risk. Ann Intern Med. 1990; 112:182–6. (PubMed).
 Bernstein L, Ross RK. Endogenous hormones and breast cancer risk. Epidemiol Rev. 1993; 15:48–65. (PubMed).
 Ballard-Barbash R. Anthropometry and breast cancer: body size- a moving target. Cancer. 1994; 74(3 Suppl):1090–100. (PubMed).
 Del Giudice ME, Fantus IG, Ezzat S, et al. Insulin and related factors in premenopausal breast cancer risk. Breast Cancer Res Treat. 1998; 47:111–20. (PubMed).
 Persson I. Estrogens in the causation of breast, endometrial and ovarian cancers- evidence and hypothesis from epidemiological findings. J Steroid Biochem Mol Biol. 2000; 74:357–64. (PubMed).
 Verkasalo PK, Thomas HV, Appleby PN, et al. Circulating levels of sex hormones and their relation to risk factors for breast cancer: a crosssectional study in 1092 pre- and postmenopausal women (United Kingdom) Cancer Causes Control. 2001; 12:47–59. (PubMed).
 World Health Organisation Technical Report Series 854. Geneva: WHO; 1995. Physical status: The use and Interpretation of Anthropometry. Report of a WHO Expert Committee; pp. 427–30.
 Byers T. Nutritional risk factors for breast cancer. Cancer. 1994; 74(1 Suppl):288–95. (PubMed).
 Michels KB. The contribution of the environment (especially diet) to breast cancer risk. Breast Cancer Res. 2002; 4:58–61. (PMC free article) (PubMed).
 Lam PB, Vacek PM, Geller BM, et al. The association of increased weight, Body mass index and tissue density with the risk of breast carcinoma in Vermont. Cancer. 2000; 89:369–75. (PubMed).
 Strain JJ, Bokje E, van’t Veer P, et al. Thyroid hormones and selenium status in breast cancer. Nutr Cancer. 1997; 27:48–52. (PubMed).
 Pathak DR, Whittemore AS. Combined effects of body size, parity, and menstrual events on breast cancer incidence in seven countries. Am J Epidemiol. 1992; 135:153–68. (PubMed).
 Tornberg SA, Carstensen JM. Relationship between Quetelet's index and cancer of breast and female genital tract in 47,000 women followed for 25 years. Br J Cancer. 1994; 69:358–61. (PMC free article) (PubMed).
 Zhu Z, Parviainen M, Männistö S, et al. Vitamin E concentration in breast adipose tissue of breast cancer patients (Kuopio, Finland) Cancer Causes Control. 1996; 7:591–5. (PubMed).
 Galanis DJ, Kolonel LN, Lee J, et al. Anthropometric predictors of breast cancer incidence and survival in a multi-ethnic cohort of female residents of Hawaii, United states. Cancer Causes Control. 1998; 9:217– 24. (PubMed).