Kinetic and Removable of Amoxicillin Using Aliquat336 as a Carrier via a HFSLM

Authors: Teerapon Pirom, Ura Pancharoen

Abstract:

Amoxicillin is an antibiotic which is widely used to treat various infections in both human beings and animals. However, when amoxicillin is released into the environment, it is a major problem. Amoxicillin causes bacterial resistance to these drugs and failure of treatment with antibiotics. Liquid membrane is of great interest as a promising method for the separation and recovery of the target ions from aqueous solutions due to the use of carriers for the transport mechanism, resulting in highly selectivity and rapid transportation of the desired metal ions. The simultaneous processes of extraction and stripping in a single unit operation of liquid membrane system are very interesting. Therefore, it is practical to apply liquid membrane, particularly the HFSLM for industrial applications as HFSLM is proved to be a separation process with lower capital and operating costs, low energy and extractant with long life time, high selectivity and high fluxes compared with solid membranes. It is a simple design amenable to scaling up for industrial applications. The extraction and recovery for (Amoxicillin) through the hollow fiber supported liquid membrane (HFSLM) using aliquat336 as a carrier were explored with the experimental data. The important variables affecting on transport of amoxicillin viz. extractant concentration and operating time were investigated. The highest AMOX- extraction percentages of 85.35 and Amoxicillin stripping of 80.04 were achieved with the best condition at 6 mmol/L [aliquat336] and operating time 100 min. The extraction reaction order (n) and the extraction reaction rate constant (kf) were found to be 1.00 and 0.0344 min-1, respectively.

Keywords: Aliquat336, amoxicillin, HFSLM, kinetic.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1107615

References:

[1] G. Moulin, P. Cavalie, I. Pellanne, A. Chevance, A. Laval, Y. Millemann, A comparison of antimicrobial usage in human and veterinary medicine in France from 1999 to 2005, Antimicrobial Agents and Chemotherapy, 62:617–625, 2008.
[2] P. Jepsen, A population-based study of maternal use of amoxicillin and pregnancy outcome in Denmark, British Journal of Clinical Pharmacology, 55:216–221, 2003.
[3] J.C. Jimejnez, Low Bioavailability of Amoxicillin in Rats as a Consequence of Presystemic Degradation in the Intestine, Antimicrobial agents and chemotherapy, 38:842-847, 1994.
[4] S.-z. Li, X.-y. Li, D.-z. Wang, Membrane (RO-UF) filtration for antibiotic wastewater treatment and recovery of antibiotics, Separation and Purification Technology, 34:109-114, 2004.
[5] H. Goossens, M. Ferech, R.V. Stichele, M. Elseviers, Outpatient antibiotic use in Europe and association with resistance: a cross-national database study. Lancet, 365:579–587, 2005.
[6] K. Kümmerer, A. Henninger, Promoting resistance by the emission of antibiotics from hospitals and households into effluent, Clinical Microbiology and Infection, 9:1203–1214, 2003.
[7] S. Yang, K. Carlson, Evolution of antibiotic occurrence in a river through pristine, urban and agricultural landscapes, Water Research 37:4645-4656, 2003.
[8] V. Homem, L. Santos, Degradation and removal methods of antibiotics from aqueous matrices – a review, Journal of Environmental Management, 92:2304–2347, 2011.
[9] D. Fatta-Kassinos, S. Meric, A. Nikolaou, Pharmaceutical residues in environmental waters and wastewater: current state of knowledge and future research. Analytical and Bioanalytical Chemistry, 399:251–275, 2011.
[10] G.C. Sahoo, A.C. Ghosh, N.N. Dutta, Recovery of Cephalexin from dilute solution in a bulk liquid membrane, Process Biochemistry, 32:265–272, 1997.
[11] G.C. Sahoo, N.N. Dutta, Studies on emulsion liquid membrane extraction of Cephalexin, Journal of Membrane Science, 145:15–26, 1998.
[12] N. M. Kocherginsky, Q. Yang, L. Seelam, Recent advances in supported liquid membrane technology, Separation and Purification Technology, 53:171–177, 2007.
[13] X. J. Yang, A.G. Fane, C. Pin, Separation of zirconium and hafnium using hollow fibers Part I. Supported liquid membranes, Chemical Engineering Journal, 88:37–44, 2002.
[14] Baker, R.W., Membrane technology and applications. Newyork: McGraw-Hill, 2004.
[15] W. Patthaveekongka, N. Vijitchalermpong, U. Pancharoen, Selective Recovery of Palladium from Used Aqua Regia by Hollow Fiber Supported with Liquid Membrane, Korean Journal of Chemical Engineering, 20:1092-1096, 2003.