Commenced in January 2007
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Effect of Zidovudine on Hematological and Virologic Parameters among Female Sex Workers Receiving Antiretroviral Therapy (ART) in North – Western Nigeria

Authors: N. M. Sani, E. D. Jatau, O. S. Olonitola, M. Y. Gwarzo, P. Moodley, N. S. Mujahid

Abstract:

Hemoglobin (HB) indicates anemia level and by extension may reflect the nutritional level and perhaps the immunity of an individual. Some antiretroviral drugs like Zidovudine are known to cause anemia in people living with HIV/AIDS (PLWHA). A cross sectional study using demographic data and blood specimen from 218 female commercial sex workers attending antiretroviral therapy (ART) clinics was conducted between December, 2009 and July, 2011 to assess the effect of zidovudine on hematologic, and RNA viral load of female sex workers receiving antiretroviral treatment in north western Nigeria. Anemia is a common and serious complication of both HIV infection and its treatment. In the setting of HIV infection, anemia has been associated with decreased quality of life, functional status, and survival. Antiretroviral therapy, particularly the highly active antiretroviral therapy (HAART), has been associated with a decrease in the incidence and severity of anemia in HIV-infected patients who have received a HAART regimen for at least 1 year. In this study, result has shown that of the 218 patients, 26 with hemoglobin count between 5.1 – 10g/dl were observed to have the highest viral load count of 300,000 – 350,000copies/ml. It was also observed that most patients (190) with HB of 10.1 – 15.0g/dl had viral load count of 200,000 – 250,000 copies /ml. An inverse relationship therefore exists i.e. the lower the hemoglobin level, the higher the viral load count even though the test statistics did not show any significance between the two (P = 0.206). This shows that multivariate logistic regression analysis demonstrated that anemia was associated with a CD4 + cell count below 50/μL, female sex workers with a viral load above 100,000 copies/mL, who use zidovudine. Severe anemia was less prevalent in this study population than in historical comparators; however, mild to moderate anemia rates remain high. The study therefore recommends that hematological and virologic parameters be monitored closely in patients receiving first line ART regimen.

Keywords: Anemia, zidovudine, hemoglobin, female sex worker

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1107421

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References:


[1] UNAIDS AIDS Epidemic Update. Geneva, December; 2005.
[2] Karim A. Q., Karim S. S. A., Soldan., Zondi M. Reducing the risk of HIV infection among South African Sex workers – Socio economic and gender barriers. Am J. Public Health, 1995; 1521 – 1525.
[3] Davis C., Heath A., Best S. Calibration of HIV -1 working reagents for nucleic acid amplification techniques against the 1st international standard for HIV -1 RNA. Journal of Virological Methods, 2003; 107: 37 – 44
[4] Deeks S. G., Hecht F. M., Swanson M., Elbeik T., Loftus R., Cohen P. T. HIV RNA and CD4 Cell Count Response to Protease Inhibitor Therapy in an Urban AIDS Clinic: Response to Both Initial and Salvage Therapy, AIDS, 1999; 13(6):35–43.
[5] Federal Ministry of Health National seroprevalence Surveillance sentinel survey among pregnant women attending antenatal clinics in Nigeria. Abuja, Nigeria: Department of Public Health, 2010.
[6] Hecht, F.M. Bush M. P., Rawul B., Webb M., Rosenberg E., Swanson M. Use of laboratory tests and clinical symptoms for identification of primary HIV infection. AIDS, 2002; 16:1119 – 1129.
[7] Moore RD. Human immunodeficiency virus infection, anemia, and survival Clinical Infectious Diseases. 1999; 29: 44-49.
[8] Myers TW, Gelfand DH. Reverse transcription and DNA amplification by a Thermus thermophilus DNA polymerase. Biochem, 1991; 30:7661 - 6.
[9] National AIDS and STD control program technical report of the 2005 National HIV/Syphilis sero – prevalence sentinel survey among pregnant women attending antenatal clinics in Nigeria (2005): technical report.
[10] Yen – Livermann B., Brambilla D., Jackson B. Evaluation of a quality assuarance program for quantification of human immunodeficiency virus type 1 RNA in plasma by the AIDS clinical trials group virology laboratories. J Clinical Microbiology, 1996; 34: 2695 – 701.
[11] World Health Organization Manual for HIV Drug Resistance Testing using Dried Blood Spot specimens. http://www.who.int/hiv/tropics/drug resistance/dbs_ protocol accessed 2010.
[12] Holmes H., Davis C., Heath A., Best S., An international collaborative study to establish the 1st international standard for HIV – 1 RNA` for use in nucleic acid – based techniques. J Virol Methods, 2001; 92; 141 – 50.
[13] Davis C., Heath A., Best S.Caliberation of HIV -1 working reagents for nucleic acid amplification techniques against the 1st international standard for HIV-1 RNA. J Virol Meth. 2003 ; 107 : 37 – 44
[14] Louis Saccabarrozi.Sexworkers and HIV. The ‘body’ http://www.the body.com/content/art 14140 html. 2007; 1 – 4.
[15] Katlama, C. Ingrand D., Love day C. Safety and eficacy of Lamivudine – Zidovudine combination therapy in antiretroviral naive patients. A randomized controlled comparison with Zidovudine monotherapy. Lamivudine European HIV working Group. J Am Med