Modeling and Validation of Microspheres Generation in the Modified T-Junction Device
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Modeling and Validation of Microspheres Generation in the Modified T-Junction Device

Authors: Lei Lei, Hongbo Zhang, Donald J. Bergstrom, Bing Zhang, K. Y. Song, W. J. Zhang

Abstract:

This paper presents a model for a modified T-junction device for microspheres generation. The numerical model is developed using a commercial software package: COMSOL Multiphysics. In order to test the accuracy of the numerical model, multiple variables, such as the flow rate of cross-flow, fluid properties, structure, and geometry of the microdevice are applied. The results from the model are compared with the experimental results in the diameter of the microsphere generated. The comparison shows a good agreement. Therefore the model is useful in further optimization of the device and feedback control of microsphere generation if any.

Keywords: CFD modeling, validation, microsphere generation, modified T-junction.

Digital Object Identifier (DOI): doi.org/10.5281/zenodo.1100727

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[1] L. Amaya bower and T. Lee, "Lattice Boltzmann simulations of bubble formation in a microfluidic T-junction," Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, vol. 369, pp. 2405-2413, 2011.
[2] S. Arias, D. Legendre, and R. Gonzalez-Cinca, "Numerical simulation of bubble generation in a T-junction," Computers & Fluids, vol. 56, pp. 49-60, Mar 2012.
[3] N. C. Chen, J. Z. Wu, H. M. Jiang, and L. C. Dong, "CFD Simulation of Droplet Formation in a Wide-Type Microfluidic T-Junction," Journal of Dispersion Science and Technology, vol. 33, pp. 1635-1641, 2012.
[4] T. Glawdel and C. L. Ren, "Droplet formation in microfluidic T-junction generators operating in the transitional regime. III. Dynamic surfactant effects," Physical Review E, vol. 86, Aug 13 2012.
[5] X. Li, F. Li, J. Yang, H. Kinoshita, M. Oishi, and M. Oshima, "Study on the mechanism of droplet formation in T-junction microchannel," Chemical Engineering Science, vol. 69, pp. 340-351, Feb 13 2012.
[6] M. B. Mbanjwa, K. Land, L. L. Jewell, and I. M. Gledhill, "Experimental and numerical studies of emulsion formation in a microfluidic T-junction," presented at the AfriCOMP11: Second African Conference on Computational Mechanics, University of Cape Town, Cape Town, 2011.
[7] J. Sivasamy, T. N. Wong, N. T. Nguyen, and L. T. H. Kao, "An investigation on the mechanism of droplet formation in a microfluidic T-junction," Microfluidics and Nanofluidics, vol. 11, pp. 1-10, Jul 2011.
[8] K. Wang, Y. C. Lu, J. Tan, B. D. Yang, and G. S. Luo, "Generating gas/liquid/liquid three-phase microdispersed systems in double T-junctions microfluidic device," Microfluidics and Nanofluidics, vol. 8, pp. 813-821, Jun 2010.
[9] J. Wehking, M. Gabany, L. Chew, and R. Kumar, "Effects of viscosity, interfacial tension, and flow geometry on droplet formation in a microfluidic T-junction," Microfluidics and Nanofluidics, vol. 16, pp. 441-453, 2014/03/01 2014.
[10] S. Yeom and S. Y. Lee, "Size prediction of drops formed by dripping at a micro T-junction in liquid-liquid mixing," Experimental Thermal and Fluid Science, vol. 35, pp. 387-394, Feb 2011.
[11] R. F. Meyer, W. B. Rogers, M. T. McClendon, and J. C. Crocker, "Producing Monodisperse Drug-Loaded Polymer Microspheres via Cross-Flow Membrane Emulsification: The Effects of Polymers and Surfactants," Langmuir, vol. 26, pp. 14479-14487, Sep 2010.
[12] M. Pathak, "Numerical simulation of membrane emulsification: Effect of flow properties in the transition from dripping to jetting," Journal of Membrane Science, vol. 382, pp. 166-176, Oct 15 2011.
[13] R. D. Hancocks, F. Spyropoulos, and I. T. Norton, "Comparisons between membranes for use in cross flow membrane emulsification," Journal of Food Engineering, vol. 116, pp. 382-389, 2013.
[14] T. Schneider, G. H. Chapman, and U. O. Häfeli, "Effects of chemical and physical parameters in the generation of microspheres by hydrodynamic flow focusing," Colloids and surfaces B: biointerfaces, vol. 87, pp. 361-368, 2011.
[15] Q. J. Zhang, G. Y. Lin, Y. Wang, F. J. Yang, L. Ba, and D. G. Fu, "Formation of monodisperse cross-linked nanospherial condensates based on flow-focusing and droplet diffusion techniques," Colloids and Surfaces a-Physicochemical and Engineering Aspects, vol. 384, pp. 53-57, Jul 2011.
[16] K. Song, "Design and fabrication of novel microfluidic systems for microsphere generation," Doctor of Philosophy, Department of Biomedical Engineering, University of Saskatchewan, 2011.
[17] L. Lei, H. Zhang, D. J. Bergstrom, B. Zhang, and W. Zhang, "Modeling of droplet generation by a modified T-junction device using COMSOL," presented at the International Conference on Mechanical Design and Manufacturing, Hong Kong, 2014.
[18] K. Song and W. Zhang, "Design of a microchannel system using axiomatic design theory for size-controllable and monodispersed microspheres by enhanced perturbation," The International Journal of Advanced Manufacturing Technology, vol. 64, pp. 769-779, 2013.
[19] S. Osher and J. A. Sethian, "Fronts propagating with curvature-dependent speed-algorithms based on Hamilton-Jacobi formulations," Journal of Computational Physics, vol. 79, pp. 12-49, Nov 1988.