@article{(Open Science Index):https://publications.waset.org/pdf/10000421, title = {Anti-Inflammatory Activity of Topical Anthocyanins by Complexation and Niosomal Encapsulation}, author = {Aroonsri Priprem and Sucharat Limsitthichaikoon and Suttasinee Thappasarapong}, country = {}, institution = {}, abstract = {Anthocyanins are natural pigments with effective UV protection but their topical use could be limited due to their physicochemical characteristics. An attempt to overcome such limitations by complexation of 2 major anthocyanin-rich sources, C. ternatea and Z. mays, has potentiated its use as topical antiinflammatory. Cell studies indicate no cytotoxicity of the anthocyanin complex (AC) up to 1 mg/ml tested in HaCaT and human fore head fibroblasts by MTT. Croton oil-induced ear edema in Wistar rats suggests an effective dose of 5 mg/cm2 of AC as a topical anti-inflammatory in comparison to 0.5 mg/cm2 of fluocinolone acetonide. Niosomal encapsulation of the AC significantly prolonged the anti-inflammatory activity particularly at 8 h after topical application (p = 0.0001). The AC was not cytotoxic and its anti-inflammatory and activity was dose-dependent and prolonged by niosomal encapsulation. It has also shown to promote collagen type 1 production in cell culture. Thus, AC could be a potential candidate for topical anti-inflammatory agent from natural resources. }, journal = {International Journal of Chemical and Molecular Engineering}, volume = {9}, number = {2}, year = {2015}, pages = {142 - 146}, ee = {https://publications.waset.org/pdf/10000421}, url = {https://publications.waset.org/vol/98}, bibsource = {https://publications.waset.org/}, issn = {eISSN: 1307-6892}, publisher = {World Academy of Science, Engineering and Technology}, index = {Open Science Index 98, 2015}, }